CRLF1 (Gene)

Organism:

Homo sapiens

Synonyms:CISS, CISS1, CLF, CLF-1, CRLF1, ENTREZ:9244, HGNC:2364, MIM:604237, NM_004750, NP_004741, NR6, cytokine receptor like factor 1, zcytor5

Omim:OMIM:604237

Id:ENSG00000006016

Hgnc:HGNC:2364

Entrez:9244

Ensembl:ENSG00000006016

Description:cytokine receptor like factor 1

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CRLF1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CRLF1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CRLF1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CRLF1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CRLF1.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE142588 cinobufagin 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118816 Myo1c knockdown podocyte 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE238213 dopamine 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 3 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 7 v 14 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE142588 2 V 1 CINOBUFAGIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 10 v 6 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE118939 NRAS knockout 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE142588 cinobufagin 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118816 Myo1c knockdown podocyte 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE119424 GSE120214 TBXT brachyury inhibition 7 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE238213 dopamine 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 7 v 14 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE142588 2 V 1 CINOBUFAGIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 10 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE118939 NRAS knockout 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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