CFDE Data Portal

FEATURED

Mild Cognitive Impairment Use Case

Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.

FEATURED

Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets

Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.

FEATURED

Mild Cognitive Impairment Use Case

Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.

FEATURED

Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets

Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.

FEATURED

Mild Cognitive Impairment Use Case

Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.

FEATURED

Cell Surface Targets for Individual Cancer Patients Analyzed with Common Fund Datasets

Given RNA-seq samples from a patient tumor, we screen for targets which are highly expressed in the tumor but lowly expressed across all healthy human tissues in GTEx. Detailed information about the selected target are queried from several DCCs.

All Use Cases

Explore different use cases that utilizes data from different CFDE participating programs

Data Distillery Knowledge Graph

Frontotemporal Dementia Use Case

For genes that are correlated with frontotemporal dementia, identify extracellular RNAs (exRNAs) that may be detected in human biofluids and thus serve as non-invasive disease biomarkers.

ProKN

Phosphorylation sites of a perturbagen

Find phosphorylation sites that are likely to be downregulated by a perturbagen

GeneSetCart

Analysis of Alexander Disease Gene Sets

Alexander disease (AxD) is caused by a GFAP gene mutation, leading to an accumulation of GFAP protein. This excess GFAP leads to Rosenthal fibers (RFs) in astrocytes. We use the G2SG pipeline to analyze gene sets created by comparing gene expression samples obtained from GEO of wild type (WT) or controls to Alexander disease samples.

Playbook Workflow Builder

Related Proteins/Metabolites across DCCs

Using directly related proteins to a gene of interest, we return a slew of related information to the gene protein network from different DCCs.

Data Distillery Knowledge Graph

CES1 Use Case

Display drugs that up or down regulate the gene CES1 from LINCS as well as tissues where it is highly expressed based on assertions from GTEx.

Data Distillery Knowledge Graph

Liquid Biopsy of Dexamethasone Response

Find genes that are up-regulated by dexamethasone, (2) loci expressed in exRNA that overlap RBP binding regions, (3) the RBP that overlaps the locus, and (4) the biofluid(s) where locus was expressed in exRNA.

ProKN

Phenotypes associated with altered phosphorylation events

Explore phenotypes associated with altered phosphorylation events of a perturbagen.

Data Distillery Knowledge Graph

Mild Cognitive Impairment Use Case

Find all IDG and GTEx assertions that may be related to mild cognitive impairment and any tissue type.

Playbook Workflow Builder

CFDE Knowledge about a Variant

We query several CFDE data sources for information about the variant provided and about the closest gene to that variant.

Playbook Workflow Builder

Associations between Two Variants

Given two variants, we find their closest genes and present combined knowledge about them including their expression in tumors & healthy tissue, interactions between the two proteins, and gene sets containing the two genes.

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.