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KRAS (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:'C-K-RAS, C-K-RAS, CFC2, ENTREZ:3845, HGNC:6407, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras 2, K-Ras, KI-RAS, KRAS proto-oncogene, GTPase, KRAS, KRAS1, KRAS2, MIM:190070, NM_001369786, NM_001369787, NM_004985, NM_033360, NP_001356715, NP_001356716, NP_004976, NP_203524, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2
Omim:OMIM:190070
Id:ENSG00000133703
Hgnc:HGNC:6407
Entrez:3845
Ensembl:ENSG00000133703
Description:KRAS proto-oncogene, GTPase
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View KRAS's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with KRAS.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using KRAS.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for KRAS.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with KRAS.

Results found

Linked to

 

Label

Description

 

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GSE239844 crizotinib 1 v 10 human dn

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GSE67266 7 V 3 ETOPOSIDE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

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GSE218378 PBX1 overexpression HCT 116 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE48812 sulforaphane 2 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE176366 vincristine 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE128240 0 V 1 CYCLOPHOSPHAMIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE190937 AHCY MAT2A knockout Rael 2 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE232944 APC CTNNB1 overexpression HT29 1 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE74490 0 V 1 TRIPTOLIDE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE199107 tryptophan 6 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239844 crizotinib 1 v 10 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE67266 7 V 3 ETOPOSIDE MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE218378 PBX1 overexpression HCT 116 1 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE48812 sulforaphane 2 v 5 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE176366 vincristine 3 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE128240 0 V 1 CYCLOPHOSPHAMIDE MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE190937 AHCY MAT2A knockout Rael 2 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE232944 APC CTNNB1 overexpression HT29 1 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE74490 0 V 1 TRIPTOLIDE MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.