Synonyms:ENTREZ:4005, HGNC:6642, LIM domain only 2, LMO-2, LMO2, MIM:180385, NM_001142315, NM_001142316, NM_005574, NP_001135787, NP_001135788, NP_005565, RBTN2, RBTNL1, RHOM2, TTG2, XM_005252921, XM_017017727, XM_017017728, XM_017017729, XM_017017730, XM_017017731, XM_017017732, XM_017017733, XP_005252978, XP_016873216, XP_016873217, XP_016873218, XP_016873219, XP_016873220, XP_016873221, XP_016873222
Omim:OMIM:180385
Id:ENSG00000135363
Hgnc:HGNC:6642
Description:LIM domain only 2
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]