PNMT (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:5409, HGNC:9160, MIM:171190, NM_002686, NP_002677, NR_073461, PENT, PNMT, PNMTase, XM_011524909, XP_011523211, phenylethanolamine N-methyltransferase

Omim:OMIM:171190

Id:ENSG00000141744

Hgnc:HGNC:9160

Entrez:5409

Ensembl:ENSG00000141744

Description:phenylethanolamine N-methyltransferase

The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PNMT's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PNMT.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PNMT.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PNMT.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PNMT.

Results found

Linked to

	Label	Description
	GSE108464 AZ-628 11 v 12 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE121425 GSE121426 LSD1 inhibition SET-2 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE143782 calcitriol 3 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE225901 dexamethasone 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE119345 bexarotene T cell 0 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE154074 1 V 0 BLEOMYCIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE195559 NOTCH1 knockout endothelial cell cardiac muscle cell stem cell 6 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE76425 lenalidomide 0 v 10 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE76425 IKZF1 CRBN MEIS2 IKZF3 inhibition Lenalidomide 0 v 10 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE76425 lenalidomide 0 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE108464 AZ-628 11 v 12 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE121425 GSE121426 LSD1 inhibition SET-2 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE143782 calcitriol 3 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE225901 dexamethasone 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE119345 bexarotene T cell 0 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE154074 1 V 0 BLEOMYCIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE195559 NOTCH1 knockout endothelial cell cardiac muscle cell stem cell 6 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE76425 lenalidomide 0 v 10 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE76425 IKZF1 CRBN MEIS2 IKZF3 inhibition Lenalidomide 0 v 10 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE76425 lenalidomide 0 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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