ALAS2 (Gene)

Organism:

Homo sapiens

Synonyms:5'-aminolevulinate synthase 2, ALAS-E, ALAS2, ALASE, ANH1, ASB, ENTREZ:212, HGNC:397, MIM:301300, NM_000032, NM_001037967, NM_001037968, NM_001037969, NP_000023, NP_001033056, NP_001033057, SIDBA1, XLDPP, XLEPP, XLSA

Omim:OMIM:301300

Nci:C191908

Id:ENSG00000158578

Hgnc:HGNC:397

Entrez:212

Ensembl:ENSG00000158578

Description:5'-aminolevulinate synthase 2

The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ALAS2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ALAS2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ALAS2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ALAS2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ALAS2.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE217552 fisetin 3 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE58724 1 V 0 OXYMETHOLONE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE201309 matrine 5 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE201309 matrine 4 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE217552 3 V 0 FISETIN HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE210093 TAF15 overexpression A-549 3 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE201309 matrine 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE192710 ZIC2 ZNF423 inhibition stem cell 4 v 6 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE182181 1 V 0 RICOLINOSTAT HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE217552 fisetin 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE58724 1 V 0 OXYMETHOLONE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE201309 matrine 5 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE201309 matrine 4 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE217552 3 V 0 FISETIN HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE210093 TAF15 overexpression A-549 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE201309 matrine 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE192710 ZIC2 ZNF423 inhibition stem cell 4 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE182181 1 V 0 RICOLINOSTAT HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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