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CYP7A1 (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:CP7A, CYP7, CYP7A1, CYPVII, ENTREZ:1581, HGNC:2651, MIM:118455, NM_000780, NP_000771, cytochrome P450 family 7 subfamily A member 1
Omim:OMIM:118455
Id:ENSG00000167910
Hgnc:HGNC:2651
Entrez:1581
Ensembl:ENSG00000167910
Description:cytochrome P450 family 7 subfamily A member 1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP7A1's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP7A1.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP7A1.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP7A1.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP7A1.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE217115 3 V 5 ALECTINIB MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE129389 0 V 4 TROPIFEXOR MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE130246 enzalutamide UM 1 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE258991 enzalutamide DK1 [Tursiops] 5 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE109140 2 V 3 VALPROIC ACID HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE95685 2 V 3 TCPOBOP MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE181517 2 V 1 DOXORUBICIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE122979 GSE122980 LCL-161 MCF-7 2 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE130246 1 V 3 ENZALUTAMIDE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE130246 enzalutamide UM 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE217115 3 V 5 ALECTINIB MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE129389 0 V 4 TROPIFEXOR MOUSE UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE130246 enzalutamide UM 1 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE258991 enzalutamide DK1 [Tursiops] 5 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE109140 2 V 3 VALPROIC ACID HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE95685 2 V 3 TCPOBOP MOUSE DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE181517 2 V 1 DOXORUBICIN HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE122979 GSE122980 LCL-161 MCF-7 2 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE130246 1 V 3 ENZALUTAMIDE HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE130246 enzalutamide UM 1 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.