CYP8B1 (Gene)

Organism:

Homo sapiens

Synonyms:CP8B, CYP12, CYP8B1, ENTREZ:1582, HGNC:2653, MIM:602172, NM_004391, NP_004382, cytochrome P450 family 8 subfamily B member 1

Omim:OMIM:602172

Id:ENSG00000180432

Hgnc:HGNC:2653

Entrez:1582

Ensembl:ENSG00000180432

Description:cytochrome P450 family 8 subfamily B member 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CYP8B1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CYP8B1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CYP8B1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CYP8B1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CYP8B1.

Results found

Linked to

	Label	Description
	GSE216988 GSE216989 decitabine 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE168596 2 V 3 ADIPONECTIN MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE210655 3 V 2 CISPLATIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE214596,GSE214598 1 V 0 ROSIGLITAZONE MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE220520 5 V 4 ETHANOL MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE56010 adenosine 4 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE120792 BRCA1 inhibition Interferons 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE129389 0 V 3 TROPIFEXOR MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE205332 1 V 0 QUEUINE HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE154936 3 V 4 REMDESIVIR HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS

GSE216988 GSE216989 decitabine 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE168596 2 V 3 ADIPONECTIN MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE210655 3 V 2 CISPLATIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE214596,GSE214598 1 V 0 ROSIGLITAZONE MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE220520 5 V 4 ETHANOL MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE56010 adenosine 4 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE120792 BRCA1 inhibition Interferons 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE129389 0 V 3 TROPIFEXOR MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE205332 1 V 0 QUEUINE HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE154936 3 V 4 REMDESIVIR HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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