PENK (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)

Synonyms:ENTREZ:5179, HGNC:8831, MIM:131330, NM_001135690, NM_006211, NP_001129162, PE, PENK, PENK-A, proenkephalin

Omim:OMIM:131330

Id:ENSG00000181195

Hgnc:HGNC:8831

Entrez:5179

Ensembl:ENSG00000181195

Description:proenkephalin

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PENK's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PENK.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PENK.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PENK.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PENK.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	Ataxia Phenotype (Entity type)	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...
	GSE217452 docetaxel 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE238213 dopamine 1 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE261563 CX-5461 2 v 4 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE167173 PD-L1 knockdown 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE94849 7 V 5 PINOMETOSTAT HUMAN DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE92457 9 V 12 ETHANOL MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE217452 2 V 1 DOCETAXEL HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE155852 0 V 2 APIGENIN MOUSE UP Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

GSE217452 docetaxel 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE238213 dopamine 1 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE261563 CX-5461 2 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE167173 PD-L1 knockdown 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE94849 7 V 5 PINOMETOSTAT HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE92457 9 V 12 ETHANOL MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE217452 2 V 1 DOCETAXEL HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE155852 0 V 2 APIGENIN MOUSE UP

Gene Set (Entity type)

A Gene Set from LINCS

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Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.