SRD5A2 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:6716, HGNC:11285, MIM:607306, NM_000348, NP_000339, SRD5A2, XM_011533069, XM_011533072, XP_011531371, XP_011531374, steroid 5 alpha-reductase 2

Omim:OMIM:607306

Id:ENSG00000277893

Hgnc:HGNC:11285

Entrez:6716

Ensembl:ENSG00000277893

Description:steroid 5 alpha-reductase 2

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SRD5A2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with SRD5A2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SRD5A2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SRD5A2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SRD5A2.

Results found

Linked to

	Label	Description
	GSE199204 GSE211619 glutamine 4 v 6 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE103068 0 V 3 VOLASERTIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE150669 0 V 1 ROXADUSTAT MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS
	GSE212231 GSE218491 SHP2 inhibition 3 v 5 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE239844 crizotinib 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE197092 SNRPE knockdown SMMC-7721 1 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE199204,GSE211619 4 V 6 GLUTAMINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE133087 metformin 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE133087 1 V 2 METFORMIN HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE172020 0 V 2 TESTOSTERONE MOUSE DN Gene Set (Entity type)	A Gene Set from LINCS

GSE199204 GSE211619 glutamine 4 v 6 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE103068 0 V 3 VOLASERTIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE150669 0 V 1 ROXADUSTAT MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

GSE212231 GSE218491 SHP2 inhibition 3 v 5 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE239844 crizotinib 4 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE197092 SNRPE knockdown SMMC-7721 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE199204,GSE211619 4 V 6 GLUTAMINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE133087 metformin 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE133087 1 V 2 METFORMIN HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE172020 0 V 2 TESTOSTERONE MOUSE DN

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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