Description:The LINCS PCCSE uses two high-throughput liquid chromatography-mass spectrometry (LCMS) assays to study the proteomic changes induced by drug and genetic perturbations. P100 monitors ~100 phosphorylated peptides from cellular proteins that serve as a reduced representation of the phosphoproteome. The files available here contain P100 data for 90 small-molecule perturbations in six cell lines (five cancer cell lines and a neurodevelopmental cell model).