PR001918 (Project)

Dcc Asset:

MW submission packet 20260310.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Child Project:

PPR00001

Project (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8ST6K

Description:The embryonic cerebrospinal fluid (eCSF) is critical for the developing central nervous system (CNS), from neurogenesis to lifelong cognitive functions. Changes in eCSF composition due to inflammation can impact brain function. We recently identified an abnormal cytokine signature in eCSF following maternal immune activation (MIA), a mouse model of autism spectrum disorder (ASD). We hypothesized that MIA leads to other alterations in eCSF composition and employed untargeted metabolomics to profile changes in the eCSF metabolome in mice after inducing MIA with polyI:C. We report these data here as a resource, including a comprehensive MS1 and MS2 reference dataset, and present additional datasets comparing two mouse strains (CD-1 and C57Bl/6) and two developmental time points (E12.5 and E14.5). Targeted metabolomics further validated changes in eCSF upon MIA. We show a significant elevation of glucocorticoids and kynurenine pathway related metabolites. Both pathways are relevant for suppressing inflammation or could be informative as disease biomarkers. Our resource should inform future mechanistic studies regarding the etiology of MIA neuropathology and roles and contributions of eCSF metabolites to brain development.

Results found

Linked to

	Label	Description
	SU003194 Subject (Entity type)	A subject produced as part of the PR001918 project
	SA332850 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332697 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332800 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332865 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332925 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332861 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332880 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332802 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project
	SA332777 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR001918 project