Description:This project utilizes samples from a cohort of patients undergoing bariatric surgery. Plasma and adipose tissue samples were collected before and after bariatric surgery. Both subcutaneous and visceral adipose tissue were collected. Lipophilic pollutants, particularly persistent organic pollutants (POPs), bioaccumulate in adipose tissue. Therefore, we performed untargeted analysis with LC and GC-HRMS to measure chemicals and metabolites in the samples. These pollutant measures can then be linked to clinical and vascular parameters of cardiometabolic risk and to study the impact of weight loss on chemical levels following marked (20-30%) weight loss.