Description:Cystic fibrosis (CF), also known as mucoviscidosis, is a rare autosomal recessive genetic disease. It is caused by a mutation in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which disrupts the normal function of the chloride ion channel. Clinical manifestations of CF typically include recurrent respiratory infections, chronic airway inflammation, progressive decline in lung function, and intermittent pulmonary exacerbations. The primary aim of our study is to identify plasma biomarkers in patients with cystic fibrosis through untargeted metabolomic and lipidomic analyses, with the goal of enabling early detection, accurate diagnosis, and effective monitoring of the disease.